|McCoy, Scotty, and Sulu do not appear in this episode which had such a poorly developed script when they began filming, Gene Roddenberry had to make revisions at the same time. New pages had to be rushed to the set regularly simply to continue production of the episode creating some periods of waiting for the next update. This is the only episode which feature Nurse Chapel prominently. The novelization of the episode was adapted by James Blish.|
The graphic used for planet Exo-III will be used again for the episode "The Tholian Web".
The file photo of Roger Corby shows him wearing an old-style recycled from "The Cage" and "Where No Man Has Gone Before". This would indicate that he served with Starfleet at one point.This could also indicate that he spent time on a Starfleet vessel and was given a uniform to wear in similar fashion to what Charlie Evans was given to wear in "Charlie X".
Christine Chapel asks Mr. Spock "Have you ever been engaged?" This is a question which will be answered in the episode "Amok Time".
The footage showing the surface of planet Exo-III will be recycled in the episode "All Out Yesterdays"
Crewman Matthews, played by Vince Deadrick, has the honour of being the first "red shirt" to be killed in an episode.
Budd Albright returns in this episode as Rayburn. He appeared previously in The Man Trap as the crewman found dead in the hallway.
This marks the only appearance of Ted Cassidy as Ruk for the series, although he did provide his voice for "The Corbomite Maneuver" and "Arena". Ironically, since his character in this episode is able to mimic the voices of others, many of his lines are actually provided by other actors.[/i].
The weapons used by Brown and Andrea are recycled from "The Cage" and "Where No Man Has Gone Before".
While Captain Kirk has a discussion with his android double, Kirk's brother George Samuel Kirk is mentioned for the first time.
Used as a key element in a Saturday Night Live skit featuring William Shatner, Captain Kirk retrieves a command packet from the safe in his quarters. Giving the buttons the numeric values of 1 to 5 moving left to right, the combination is 5-5-4-3-3-4. Pressing button 3 again closes the safe.
After leaving his quarters, the Kirk android is shown walking down the corridor without the command packet in hand. This footage is recycled from "The Man Trap".
When Captain Kirk kisses Andrea, he really kisses her. William Shatner appears to really lay one on Shirley Jackson, leaving finger marks on her arm and making her lips swell slightly from the pressure of the kiss. When he is finished there appears to be more lip gloss on Shatner than on Jackson.
When Ruk refers to 'The Old Ones', it is likely a reference to the Cthulhu mythos by H.P. Lovecraft. H.P Lovecraft was Robert Bloch's mentor.
What Are Little Girls Made of is a complex discussion on the concept of humanity. What is it that makes you human? Is it simply life that makes you human or the the thoughts of the individual that make you human? Can humanity live beyond the restrictions of the body? Roger Corby thought that he had found the solution having transferred his consciousness into the form of an android, but when he concluded that it had not worked out the way he had planned, he ended his existence along with his creation Andrea. Strangely enough, it took human understanding to make this decision, therefore he could have been right all along.